Study pinpoints the cluster of neurons that tell mice to eat, drink, and move around less when they're fighting bacterial infections. We tend to eat, drink, and move less when we're feeling under the weather. And we're not alone -- most animals reduce those same three behaviors when they're fighting an infection.
Now, a new study pinpoints the cluster of neurons that control these responses, referred to as sickness behaviors. By provoking immune responses in mice, researchers demonstrated that a specific population of cells in the brainstem potently induce three telltale sickness behaviors. In addition, inhibiting these neurons blunts each of these behavioral elements of the sickness response. The findings, published in Nature, directly link inflammation to neural pathways regulating behavior, offering insight into how the immune system interacts with the brain "We are still in the early days of trying to understand the brain's role in infection," says Jeffrey M. Friedman, Marilyn M. Simpson Professor at The Rockefeller University. "But with these results, we now have a unique opportunity to ask: What does your brain look like when you're sick?" Read more...
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